The Role of Oncogenes in Signal Transduction

نویسندگان

  • Ligaya L. Stice
  • Cyrus Vaziri
  • Douglas V. Faller
چکیده

1. Abstract 2. Introduction: The role of oncogenes in signal transduction 2.1.Platelet-derived growth factor receptor signal transduction 2.1.1.Cellular responses to platelet-derived growth factor 2.2.Ras in mitogenesis and differentiation 2.2.1.Regulation of p21 activity 3. PDGF response in cells transformed by p21 3.1.Ras revertants as a tool for studying PDGF-betaR signaling 4. Molecular basis of aberrant PDGF-betaR signaling 4.1.Repression of PDGF-betaR expression in p21 -expressing cells 4.1.1.Cell cycle influences on PDGF-betaR expression 4.1.2.Transcriptional regulation of PDGF-betaR expression 4.2.Identification of a p21-induced inhibitor of PDGF-betaR activation 4.2.1.Candidate inhibitors of PDGF-betaR activation 4.2.2.Mechanisms of action of the PDGF-betaR inhibitor 5. Cell morphology and PDGF-betaR phosphorylation 6. The cytoskeleton as a link between RAS, RHO and RAC 6.1.Modulation of PDGF-betaR signaling by integrins 7. Summary 8. References

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تاریخ انتشار 2003